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Information provided on personal blogs and commercial websites advises fitness and bodybuilding enthusiasts to supplement with ostarine at dose ranges from 10 mg to 30 mg for at least 12 weeks. The most commonly prescribed weight maintenance dosage is 150 mg daily with at least one daily dose of 30 mg to 600 mg (2.5 mg to 8.5 mg in an 8 to 12 weekly dosage). One study reported the efficacy of ostarine in lowering testosterone levels and restoring metabolic regulation. Topical application of ostarine is generally not recommended in obese individuals and in subjects with medical conditions requiring surgery or blood transfusions. FDA review The FDA published a critical analysis of ostarine's efficacy and safety (http://www.fda.gov/Drugs/DrugSafety/ucm141317.htm). The agency concluded that it appears to have little to no actionable evidence to consider when recommending use of ostarine as a medication for obesity. At the time the critical analysis was published, the FDA had not reviewed clinical trials on ostarine. Safety Ostarine is not approved for use in the U.S. as a medication on medical grounds. FDA concerns have been raised regarding ostarine's potential toxicity (http://www.fda.gov/Drugs/DrugSafety/ucm141318.htm). Ostarine was the subject of a major safety concern in 2012 after one patient died in an in-patient setting due to sepsis caused by ostarine use. The FDA issued new guidance regarding ostarine's use (http://www.fda.gov/drugs/DrugSafety/ucm141318.htm). FDA has recently proposed changes to FDA's position on ostarine that will change the scope of the agency's review of the drug's safety (http://www.fda.gov/DrugSafety/ucm162033.htm). The FDA has determined that ostarine should be considered when considering treatment recommendations for obese individuals or those at risk for surgical complications, and will continue to be a consideration in determining the dosage of ostarine used in non-surgical treatment of obesity. Potential drug interactions The most common drug interaction between ostarine and other medications is with certain other drugs, such as blood pressure medications. Other potential drug interactions include depression, diabetes mellitus, and nausea and vomiting. FDA has been asked to clarify that ostarine should generally not be used within 72 hours of prior administration of an antihistamine or beta blocker and that ostarine should not be used for more than 72 hours in patients who are taking Related Article: